Manehattan is a large metropolitan area, and is home to many high-class ponies. It is largely based off of Manhattan, a bourough of New York City. Like its real life counterpart, Manehattan has many skyscrapers. It is also home to many museums and theaters.
As a filly, Applejack traveled to live with her aunt and uncle, Mosely Orange and Aunt Orange, who are residents, due to a desire to live a sophisticated life, but returned to the farm, where she fit in better. Later on, it is revealed that other relatives of the Apple family, filly Babs Seed and her parents, reside in Manehattan, where Babs Seed was the target of bullying.
Manehattan is the location of Fashion Week, where designers from all over Equestria come to display their latest designs. Notably, Rarity and her friends would travel to Manehattan, where Rarity took part in Fashion Week.