- Body Color: Blue
- Hair Color: Green
- Eye Color: Red and Green
- Symbol: Unknown
Mane-iac appeared in the episode "Power Ponies". She was the antagonist of the comic book of the same name. According to the comic book's lore, she had been a regular earth pony who had fallen into a vat of chemicals and was electrocuted. The accident rendered her insane and gave her a stretchy, prehensile mane. After Spike and the Mane Six are transported into the comic book, they are forced to stop Mane-iac's plans.
Mane-iac Mayhem was released as an 2014 SDCC exclusive. She had molded hair and came with Spike, who was depicted as the superhero sidekick Humdrum, from the episode "Power Ponies".